其次，在疑难与重症卒中救治方面取得多个重大突破。提出重残率和死亡率超过80%的脑干血栓救治新策略，使重残率降低33%，死亡率降低27%，成果发表于新英格兰医学杂志（N Engl J Med）；针对极易误诊误治、重症病死率高达30%的脑静脉血栓，建立生物影像诊断新技术和多模式救治新策略，使早期确诊率提高约3倍、救治成功率提高约1倍、病死率降低2倍以上,成果写入国内外指南和国际教材（美国神经外科教材第八版《尤曼斯-温神经外科学》和美国急诊医学教科书第九版《罗森急诊医学》等）。

       第三，针对我国脑卒中以颅内动脉粥样硬化狭窄为主要病因、预防效果不佳的困境，提出束臂-脑缺血预适应新理论，研发专用治疗仪器和临床防治方案，是高危卒中年复发率降低27%，心脑血管意外发生率降低30%，成为预防脑卒中发生与复发的有效干预新手段，破解了我国特有的卒中防治难题，成果发表于高血压（Hypertension）、卒中（Stroke）、循环（Circulation）和柳叶刀神经（Lancet Neurology）等，成果入选2017年国际卒中领域重大进展。技术拓展用于高原病防治，组建北京高原适应研究康复中心。

3. 人物主要经历

       1996年09月—2001年07月，天津医科大学，获博士学位。
       2007年02月—2019年12月，首都医科大学宣武医院副院长。
       2007年08月—2009年09月，中欧国际工商学院，获工商管理硕士（MBA）。
       2017年12月—至今，北京脑重大疾病研究院院长。
       2018年08月—至今，北京高原适应研究康复中心主任。
       2019年12月—至今，首都医科大学副校长。 

4. 主要奖项
       1）2007年，国家科学技术与进步二等奖，脊髓血管畸形的基础与临床研究
       2）2021年，国家科学技术与进步二等奖，低氧与缺血适应防治缺血性脑卒中新技术体系的创研及推广应用
       3）2018年，教育部科学技术进步奖一等奖，上肢远隔缺血适应新技术的建立及其防治缺血性脑卒中的临床应用
       4）2019年，中华医学科技奖一等奖，缺血性脑卒中非药物防治新技术的创研与应用
       5）2020年，军队科学技术奖科技进步奖奖一等奖，特殊军事作业环境下*****的机制与防控策略
       6）2021年，新疆维吾尔自治区科技进步奖一等奖，新疆战略区极端环境医学军民融合平台建设及应用

5. 代表性论文
       以通讯作者在 The New England Journal of Medicine、Lancet Neurology、Nature、Circulation 等期刊发表 SCI 论文 318 篇，被引 18600 余次，H 指数 67，连续 5 年入选 Elsevier 中国高被引学者。

1)   Jovin TG, Li C, Wu L, Wu C, Chen J, Jiang C, Shi Z, Gao Z, Song C, Chen W, Peng Y, Yao C, Wei M, Li T, Wei L, Xiao G, Yang H, Ren M, Duan J, Liu X, Yang Q, Liu Y, Zhu Q, Shi W, Zhu Q, Li X, Guo Z, Yang Q, Hou C, Zhao W, Ma Q, Zhang Y, Jiao L, Zhang H, Liebeskind DS, Liang H, Jadhav AP, Wen C, Brown S, Zhu L, Ye H, Ribo M, Chang M, Song H, Chen J, Ji X*; BAOCHE Investigators. Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion. The New England Journal of Medicine. 2022 Oct 13;387(15):1373-1384.

2)   Hou C, Lan J, Lin Y, Song H, Wang Y, Zhao W, Li S, Meng R, Hao J, Ding Y, Chimowitz MI, Fisher M, Hess DC, Liebeskind DS, Hausenloy DJ, Huang J, Li Z, Han X, Yang J, Zhou J, Chen P, Zhu X, Hu P, Pang H, Chen W, Chen H, Li G, Tao D, Yue W, Gao Z, Ji X*; RICA investigators. Chronic remote ischaemic conditioning in patients with symptomatic intracranial atherosclerotic stenosis (the RICA trial): a multicentre, randomised, double-blind sham-controlled trial in China. Lancet Neurology. 2022 Dec;21(12):1089-1098.

3)   Shi Y, Zhang L, Pu H, Mao L, Hu X, Jiang X, Xu N, Stetler RA, Zhang F, Liu X, Leak RK, Keep RF, Ji X*, Chen J*;. Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury. Nature Communication. 2016 Jan 27;7:10523.

4)   Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X*, Lo EH*. Transfer ofmitochondria from astrocytes to neurons after stroke. Nature. 2016 Jul 28;535(7613):551-5

5)   Zhao W, Meng R, Ma C, Hou B, Jiao L, Zhu F, Wu W, Shi J, Duan Y, Zhang R, Zhang J, Sun Y, Zhang H, Ling F, Wang Y, Feng W, Ding Y, Ovbiagele B, Ji X*. Safety and Efficacy of Remote Ischemic Preconditioning in Patients With Severe Carotid Artery Stenosis Before Carotid Artery Stenting: A Proof-of-Concept, Randomized Controlled Trial. Circulation. 2017 Apr 4;135(14):1325-1335.

6)   Zongping Fang, Di Wu, Jiao Deng, Qianzi Yang, Xijing Zhang, Jian Chen, Shiquan Wang, Sijun Hu, Wugang Hou, Siming Ning, Yi Ding, Zhongmin Fan, Zhenhua Jiang, Junjun Kang, Yingying Liu, Jinlin Miao, Xunming Ji*, HailongDong, Lize Xiong; An MD2-perturbing peptide has therapeutic effects in rodent and rhesus monkey models of stroke. Science Translational Medicine. 2021 06 09;13(597).

7)   Jian Chen, Shuaili Xu, Hangil Lee, Longfei Wu, Xiaoduo He, Wenbo Zhao, Mo Zhang, Yanhui Ma, Yuchuan Ding, Yongjuan Fu, Chuanjie Wu, Ming Li, Miuwen Jiang, Huakun Cheng, Shengli Li, Ting Ma, Xunming Ji*, Di Wu; Hypothermic neuroprotection by targeted cold autologous blood transfusion in a non-human primate stroke model. Science bulletin.2023 Jul 30;68(14):1556-1566.

8)   Guiyou Liu, Wenbo Zhao, Haihua Zhang, Tao Wang, Zhifa Han, Xunming Ji*; rs1769793 variant reduces EGLN1 expression in skeletal muscle and hippocampus and contributes to high aerobic capacity in hypoxia. Proceedings of the National Academy of Sciences 2020 11 24;117(47):29283-29285.

9)   Huimin Wei, Huimin Jiang, Yifan Zhou, Xuechun Xiao, Chen Zhou, Xunming Ji*; Vascular endothelial cells: a fundamental approach for brain waste clearance. Brain. 2023 04 19;146(4):1299-1315.

10) Di Wu, Jian Chen, Longfei Wu, Hangil Lee, Jingfei Shi, Mo Zhang, Yanhui Ma, Xiaoduo He, Zixin Zhu, Feng Yan, Chuanjie Wu, Yunxia Duan, Yongjuan Fu, Sijie Li, Xinglong Zhi, Xuxiang Zhang, Shengli Li, Yuchuan Ding, Xunming Ji*; A clinically relevant model of focal embolic cerebral ischemia by thrombus and thrombolysis in rhesus monkeys. Nature Protocols. 2022 09;17(9):2054-2084.

11) Ran Meng, Karam Asmaro, Lu Meng, Yu Liu, Chun Ma, Chunjiang Xi, Guoqing Li, Canghong Ren, Yumin Luo, Feng Ling, Jianping Jia, Yang Hua, Xiaoying Wang, Yuchuan Ding, Eng H Lo, Xunming Ji*; Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012 Oct 30;79(18):1853-61.

12) Weili Li, Zhifeng Qi, Qingfeng Ma, Jiayue Ding, Chuanjie Wu, Haiqing Song, Qi Yang, Jiangang Duan, Lan Liu, Huining Kang, Longfei Wu, Kangxiang Ji, Wenbo Zhao, Chuanhui Li, Chenghe Sun, Na Li, Marc Fisher, Xunming Ji*, Ke Jian Liu; Normobaric Hyperoxia Combined With Endovascular Treatment for Patients With Acute Ischemic Stroke: A Randomized Controlled Clinical Trial. Neurology. 2022 08 23;99(8):e824-e834.

13) Chuanjie Wu, Chuanhui Li, Wenbo Zhao, Nanchang Xie, Feng Yan, Yajun Lian, Li Zhou, Xiaoya Xu, Yong Liang, Lu Wang, Ming Ren, Sijie Li, Xuan Cheng, Lu Zhang, Qingfeng Ma, Haiqing Song, Ran Meng, Xunming Ji*; Elevated trimethylamine N-oxide related to ischemic brain lesions after carotid artery stenting. Neurology. 2018 04 10;90(15):e1283-e1290.

14) Wenting Guo, Wenbo Zhao, Dong Li, Haiying Jia, Changhong Ren, Sijie Li, Jing Zhao, Bingxin Yu, Jian Dong, Rongfen Guo, Kun Zhu, Yu Cao, Yan Wang, Ying Wang, Zunshan Li, Zhen Wang, Dan Wang, Chengbei Hou, Derek J Hausenloy, Xi Chu, Xunming Ji*; Chronic Remote Ischemic Conditioning on Mild Hypertension in the Absence of Antihypertensive Medication: A Multicenter, Randomized, Double-Blind, Proof-of-Concept Clinical Trial.Hypertension. 2023 06;80(6):1274-1282.

15) Yuan Wang, Ran Meng, Haiqing Song, Gang Liu, Yang Hua, Dehua Cui, Lemin Zheng, Wuwei Feng, David S Liebeskind, Marc Fisher, Xunming Ji*; Remote Ischemic Conditioning May Improve Outcomes of Patients With Cerebral Small-Vessel Disease. Stroke.2017 11;48(11):3064-3072.

16) Kangxiang Ji, Chen Zhou, Longfei Wu, Weili Li, Milan Jia, Min Chu, Di Wu, Chengbei Hou, Jiangang Duan, Ran Meng, Xunming Ji*; Risk Factors for Severe Residual Headache in Cerebral Venous Thrombosis. Stroke. 2021 01;52(2):531-536.

17) Yuan Gao, Di Wu, Dachuan Liu, Mitchell Huber, Jian Chen, Xizhe Wang, Kui Lv, Xiaodu He, Huiqing Yang, Changhong Ren, Yuchuan Ding, Xunming Ji*, Xuxiang Zhang; Novel Acute Retinal Artery Ischemia and Reperfusion Model in Nonhuman Primates. Stroke. 2020 08;51(8):2568-2572.

18) Di Wu, Longfei Wu, Jian Chen, Mitchell Huber, Xiaoduo He, Shengli Li, Yuchuan Ding, Xunming Ji*; Primate Version of Modified Rankin Scale for Classifying Dysfunction in Rhesus Monkeys. Stroke. 2020 05;51(5):1620-1623.

19) Wenbo Zhao, Ruiwen Che, Shuyi Shang, Chuanjie Wu, Chuanhui Li, Longfei Wu, Jian Chen, Jiangang Duan, Haiqing Song, Hongqi Zhang, Feng Ling, Yuping Wang, David Liebeskind, Wuwei Feng, Xunming Ji*; Low-Dose Tirofiban Improves Functional Outcome in Acute Ischemic Stroke Patients Treated With Endovascular Thrombectomy. Stroke.2017 12;48(12):3289-3294.

20) Chuanjie Wu, Wenbo Zhao, Hong An, Longfei Wu, Jian Chen, Mohammed Hussain, Yuchuan Ding, Chuanhui Li, Wenjing Wei, Jiangang Duan, Chunmei Wang, Qi Yang, Di Wu, Liqiang Liu, Xunming Ji*; Safety, feasibility, and potential efficacy of intraarterial selective cooling infusion for stroke patients treated with mechanical thrombectomy. Journal of Cerebral Blood Flow and Metabolism.2018 12;38(12):2251-2260.

9. 社会任职
       北京神经科学学会 会长

       中国卒中学会脑静脉病变分会 会长

       中国老年医学会副会长兼脑血管病分会 会长

       国家卫生健康委百万减残工程专家委员会 主任

       中国老龄健康促进工程专家委员会 主任

       国际老化与疾病学会 副会长

       国际适应医学学会 主席

       Brain Circulation 主编

       Neuroprotection 主编

       Conditioning Medicine 主编

       Journal of Translational Neuroscience 主编

       Aging and Diseases  副主编

10.授权专利

       获得中国、美国、日本、加拿大等发明专利、实用新型专利和软著等专利 104 项，5项转化应用于临床。